NOX2-TRPM2 coupling promotes Zn²⁺ inhibition of complex III to exacerbate ROS production in a cellular model of Parkinson's disease.

However, while S3QEL appeared to be slightly more effective than S1QEL, this difference did not reach statistical significance, presumably because ionophores raise the metal ion concentrations to levels well beyond what the pathogenic insults can achieve.

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