Human serum proteomics reveals a molecular signature after one night of sleep deprivation.

However, when testing the gene signature within the data of timepoint 6 (14 hours of sleep deprivation), the family-wise error rate (the probability of making at least one error among all the tests conducted) and, therefore, corrected for MHT, was the lowest (0.144) of all the timepoints and the enrichment plot of the GSEA showed a trend toward a positive correlation of the upregulated proteins of the sleep deprivation condition and our gene signature ( Supplementary Figure S1 ).

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