Pharmacogenetic Variants and Plasma Concentrations of Antiseizure Drugs: A Systematic Review and Meta-Analysis.

Compared with homozygous carriers of the major UGT1A6 allele, heterozygous carriers of the UGT1A6*2 allele exhibited a 9% (95% CI, 3%-15%) reduction in valproate plasma concentrations, while the reduction in homozygous UGT1A6*2 carriers did not reach statistical significance ( Table 3 ).

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