A Review of the Role of Estrogens in Olfaction, Sleep and Glymphatic Functionality in Relation to Sex Disparity in Alzheimer's Disease.

Am J Alzheimers Dis Other Demen · 2024 · PMC11311174 · PMID 39116421

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77 In humans, an improved sense of smell was observed and found to be weakly significant in women undergoing HRT. 14 , 15 Estrogens play a direct role in olfactory processing in mammals and the preservation of olfactory memories, a process that likely begins at the olfactory bulb level. 78 , 79 Circulating estrogens have a positive impact on the development, morphology, and synaptogenesis of olfactory sensory neurons (OSNs).

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