Apolipoproteine and <i>KLOTHO</i> Gene Variants Do Not Affect the Penetrance of Fragile X-Associated Tremor/Ataxia Syndrome.

In the FXTAS individuals with an APOε2 allele, a marginal significance was observed towards a larger decline in verbal IQ (VIQ) in individuals with an APOε4 allele compared to those without an APOε4 allele ( p = 0.071).

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FXTAS stage frequencies were found to be similar in two bar plots of no APOε4 allele presentation; however, in individuals who had APOε4 allele, a higher FXTAS stage (FXTAS stage 3, 4, and 5) was observed in individuals with KL-VS (KL-VS het+ + or KL-VS hom+ ) compared to those without KL-VS, but the difference did not reach statistical significance. 2.2.

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