The genetics and epidemiology of N- and O-immunoglobulin A glycomics.

A third newly identified locus for O -glycans mapping to the gene encoding for the glycosylation enzyme polypeptide N-Acetylgalactosaminyltransferase 12 (GALNT12) showed comparable effects between TwinsUK and QMDiab, but did not reach statistical significance in the replication, likely due to the low frequency (MAF < 1.5%) of the associated SNPs in QMDiab (MAF TwinsUK > 7%; Additional file 1 : Table S15).

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