BSA-stabilized selenium nanoparticles ameliorate intracerebral hemorrhage's-like pathology by inhibiting ferroptosis-mediated neurotoxicology via Nrf2/GPX4 axis activation.

First, the H&E staining results in the hippocampus of ICH mice showed a trend toward a decrease in the number of intact neurons, along with irregular morphology and disorganized arrangement in the brain hemorrhage area.

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In addition, at seventh day after BSA-SeNPs treatment, there was an increasing trend in Nissl positive neurons both in the CA1 and CA3 areas of the hippocampus. 3.4 BSA-SeNPs ameliorated ferroptosis in hemin/erastin-exposed hippocampal neuronal cells Hippocampal neuronal cells were co-treated with hemin and BSA-SeNPs for 6 h, BSA-SeNPs overtly abrogated hemin-induced cytotoxicity ( Fig. 5 A and B).

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