Stratified analyses refine association between TLR7 rare variants and severe COVID-19.

Identification of a low-frequency TLR7 risk variant in the Spanish population In view of both the highly significant results presented above and robust prior evidence for the involvement of TLR7 in severe COVID-19, 11 , 12 , 18 , 19 , 20 , 21 more detailed investigations were performed to characterize the rare TLR7 variant associations in the present cohort.

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Nevertheless, the most significant associations were observed for the set of immunodeficiency genes ( n = 15), and this remained nominally significant even after the exclusion of TLR7 .

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