Integrated Single-Cell RNA-seq and ATAC-seq Reveals Heterogeneous Differentiation of CD4<sup>+</sup> Naive T Cell Subsets is Associated with Response to Antidepressant Treatment in Major Depressive Disorder.

At baseline, the proportion of naive T cells was significantly reduced in nonresponders compared with HCs ( p = 3.4e–05, Figure 2J ), but only showed a decreasing trend in responders ( p = 0.13).

also in 24,879 other papers

The proportion of naive T cells showed a negative trend association with the 17‐item Hamilton Depression Rating Scale (HAMD‐17, r = −0.22, p = 0.39) or 16‐item Quick Inventory of Depressive Symptomology–Self‐Report (QIDS, r = −0.37, p = 0.10) scores, which was not seen in GZMH + CD8 + Tm cells (Figure 2B–D,F–H ).

also in 1,819 other papers