Barely Significant
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Sodium Bicarbonate Treatment and Clinical Outcomes in Chronic Kidney Disease with Metabolic Acidosis: A Meta-Analysis.

Clin J Am Soc Nephrol · 2024 · PMC11321727 · PMID 38980732

2
hedged sentences
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

a nonsignificant trendP = 0.06so close (0.05 < p ≤ 0.1)
A nonsignificant trend toward elevated iPTH was noted in the bicarbonate group (SMD, 0.80; 95% CI, −0.04 to 1.64; P = 0.06, I 2 =84.82%) ( Supplemental Figure 6C ).

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In the subgroup analyses across stages 3b and 4 of CKD and different eGFR equations, the interaction effect did not reach statistical significance, with P values of 0.19 and 1, respectively.

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