p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells.

Treatment with the proteasome inhibitor MG132 showed a trend of PD-L1 protein increase in growing cells but did not affect PD-L1 levels in senescent cells, further indicating a reduced proteasomal degradation of PD-L1 in senescent cells (Fig. 3k ).

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