Long-term effects of phosphodiesterase-5 inhibitors on cardiovascular outcomes and death: a systematic review and meta-analysis.

Myocardial infarction and heart failure Regarding the secondary outcomes, five studies reported results regarding the effect of PDE5 inhibition on the incidence of myocardial infarction and the analysis of the multivariable adjusted RRs showed a trend towards a statistically significant association between PDE5i treatment and a lower incidence of myocardial infarction (RR 0.78, 95% CI 0.60–1.02) ( Supplementary material online , Figure S5 ). 20 , 21 , 28 , 29 , 31 Five studies reported results on heart failure and the pooling of results showed t

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