Stem Cell-Based Tissue Engineering for Cleft Defects: Systematic Review and Meta-Analysis.

31 Nine studies showed a trend towards higher bone formation for alveolar cleft reconstruction with cell + scaffold combination. 27 , 30 , 32 , 33 , 36 , 41 – 43 , 47 Five studies showed that the combination of cell + scaffold showed similar levels of alveolar cleft reconstruction compared to the control group. 28 , 29 , 34 , 37 , 45 Five studies expressed more bone formation for alveolar cleft reconstruction with cell + scaffold + GF combination compared to control conditions. 35 , 38 – 40 , 44 Cleft Palate A total of four articles have provided information on cell-based tissue engineering in cleft palate animal models.

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