Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription.

In accord with the current results, FC tufted astrocytes contained statistically significantly more MAPT mRNA than non-tau containing astrocytes in two of the three PSP donors, and the third donor appeared to have quantitatively more MAPT mRNA as well, although the pooled astrocyte results did not reach statistical significance [ 8 ].

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