Multi-omics insight into the metabolic and cellular characteristics in the pathogenesis of hypothyroidism.

Among the 12 cell types present in thyroid tissue, we identified eight cell types that exhibited nominally significant associations with at least one hypothyroidism dataset (Supplementary Data 12 ), which were endothelial cell, endothelial cell (APC), smooth muscle cell, T cell, macrophage, dendritic cell, B cell and B cell (Plasmacyte).

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This metabolite in the hypothyroidism group depicted a decreasing trend via UPLC − Q-TOF/MS in a study enrolled discovery and validation sets of 175 and 300 participants, respectively 20 .

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