Molecular and network disruptions in neurodevelopment uncovered by single cell transcriptomics analysis of <i>CHD8</i> heterozygous cerebral organoids.

Due to small sample size (two controls vs two KOs), the differences in many neighborhoods did not reach statistical significance, FDR <0.1 after adjusting for multiple testing, even though the fold changes appeared quite large ( Fig. 3 ).

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The decreases were highly significant for the neighborhoods predominated by cells from Oligodendrocytes (C20), Neuronal_progenitors (C3), Mesenchymal_Cilia (C15), Astrocytes (C16) and Astrocytes_progenitors (C17) (red in Fig. 3 ).

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