Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD.

Genome Med · 2024 · PMC11325793 · PMID 39148102

Europe PMC DOI

hedged sentence

0.3880

closest p · 7.8× alpha

0.3880

boldest claim

The sentences

showed a trendP = 0.388not close (p > 0.1)

The carriers of either of these variants showed a trend towards a 2.14-fold (95% CI, 0.41–11.3, P = 0.388) increased risk of severe toxicity compared to matched controls ( N = 30).

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