The DNA methyltransferase inhibitor decitabine blunts the response to a high-animal fat and protein diet in mice.

Mitochondrial DNA content was modestly but significantly higher in 8WVeh skeletal muscle than chow-fed counterparts (32.5 ± 5.5 ng/μl and 17.3 ± 5.4 ng/μl, respectively, P = 0.046), but that difference was highly significant in 16W (92.2 ± 24.1 ng/μl in 16WVeh and 7.5 ± 2.4 ng/μl in chow-fed controls, P = 8.4 × 10 –9 ).

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A set of seven short, medium, and long acylcarnitines (C3OHC, C5C, C5:1C, C5OHC, C8C, C10C, and C12:1C) were lower in HAFPD-fed 8WVeh than matched chow-fed controls, although differences reached borderline significance (0.1 < P < 0.05).

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Liver fat content was significantly increased with length of exposure to HAFPD alone ( P = 0.003, compare 8WVeh and 16WVeh), but the difference in liver fat between 8W-matched and 16W-matched chow-fed mice was marginally significant (14.0 ± 6.1 and 26.0 ± 5.1%, respectively, P = 0.061).

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