Leech <i>Poecilobdella manillensis</i> protein extract ameliorated hyperuricemia by restoring gut microbiota dysregulation and affecting serum metabolites.

However, following treatment with LTP and AP, the concentrations of ZO-1 and occludin in renal tissues showed an increasing trend ( P < 0.01) (Figure 3A and B ).

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Serum BUN levels showed a decreasing trend; however, this was not statistically significant between groups (Figure 1E ).

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The OPLS-DA results indicated a significant trend of separation in pairwise comparisons between CON and HUA groups, as well as between HUA and LTP groups (Figure 6C - F ).

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