Homotypic cell-in-cell structure as a novel prognostic predictor in non-small cell lung cancer and frequently localized at the invasive front.

Although the NRI and IDI did not reach statistical significance for predicting 1-year OS and DFS between the models with and without hoCICs ( P > 0.05), the NRI for 3- and 5-year OS was 0.363 (95% CI 0.086–0.691) and 0.333 (95% CI 0.058–0.691), respectively.

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3 D), demonstrating an increasing trend in hoCICs occurrence from the non-invasive to the invasive fronts.

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