Targeting treatment resistance: unveiling the potential of RNA methylation regulators and TG-101,209 in pan-cancer neoadjuvant therapy.

Nine regulators of 46 RMRs in Cluster1, Cluster2, and Cluster3 showed a trend of high medium, and low expression and they were more important in the random forest model according to contribution score.

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Specifically, nine regulators displayed a decreasing trend in expression from Cluster1 to Cluster3, indicating a gradient of high to low expression among these clusters (Fig. 4 G).

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