Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial.

Effect of MAG200 on joint structures of the study knee qMRI assessment indicated progression in OA in the placebo group as measured by mean percentage cartilage volume loss (-0.59 [95%CI:-1.79,0.61]), with observed mean percentage improvement in total knee cartilage volume in MAG200 10 ​× ​10 6 (0.18 [95%CI:-1.04,1.39]), 20 ​× ​10 6 (0.32 [95%CI:-0.90,1.54]) and 100 ​× ​10 6 (0.33 [95%CI:-0.86,1.51]) dose cohorts, though these changes did not reach statistical significance ( Supplementary Fig.

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