Changes in the Bile Acid Pool and Timing of Female Puberty: Potential Novel Role of Hypothalamic TGR5.

While the differences in deconjugated and secondary bile acids did not reach statistical significance in the secondary dataset, this is somewhat expected as the premenarcheal cohort was at least Tanner III, considerably older than the prepubertal cohort of the pilot study (11 vs 7 years), and more similar in reproductive stage; Tanner staging and menarche are clinical approximations of reproductive maturity and therefore not precise.

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