ENPP1 enzyme replacement therapy improves ectopic calcification but does not rescue skeletal phenotype in a mouse model for craniometaphyseal dysplasia.

However, plasma PPi levels were significantly reduced in female Ank KI/KI mice treated with vehicle ( Figure 1C ) when compared with Ank +/+ mice and showed a trend of reduction in male Ank KI/KI mice (male Ank +/+ vehicle vs male Ank KI/KI vehicle, p =.0597).

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