Neurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H<sub>2</sub>S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy.

Geroscience · 2024 · PMC11336008 · PMID 38558215

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.1000

boldest claim

The sentences

highly significantp < 0.01actually significant

borderline significantp = 0.058so close (0.05 < p ≤ 0.1)

For example, for phospho-PERK, the effect of AOAA in DS was borderline significant in males ( p = 0.058), while in females, it was highly significant ( p < 0.01).

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approaching significancep < 0.10so close (0.05 < p ≤ 0.1)

A summary of the numbers of biochemicals that achieved statistical significance ( p ≤ 0.05), as well as those approaching significance (0.05 < p < 0.10), is shown in Table S4 .

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may be significantno p-value reported

It should also be noted that there may be significant regional differences in the expression of CBS in the DS brain.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.