Effects of chronic treatment with metformin on brain glucose hypometabolism and central insulin actions in transgenic mice with tauopathy.

3 A shows that the IpGTT produced a highly significant time-dependent increase in blood glucose concentrations in both WT (F = 23.85, p < 0.0001) and Tau-VLW (F = 14.16, p < 0.0001) mice.

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Nevertheless, the effect sizes showed a trend to mRNA levels of both Insr (d = 1.185) and Irs1 (d = 1.12) be slightly higher in metformin treated mice. 3.5 Effect of metformin on the relative expression of phosphorylated and total forms of key proteins involved in the insulin signalling pathway in the frontal cortex of Tau-VLW transgenic mice

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The results regarding mortality failed to reach significance, nevertheless, we consider important to notice that 5 of 12 TC mice (41.6 %) died before reaching the age of 18 months while only 2 of 13 TM mice (13.38 %) died before 18 months of age.

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