A strong trend towards reduction in migration was observed with PLOD2 knockdown in the primary 107-I7 cell line, although non-significant (Fig. 2j ).
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Targeting PLOD2 suppresses invasion and metastatic potential in radiorecurrent prostate cancer.
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RNA sequencing of PLOD2-knockdown cells did not indicate expression changes in genes relating to these processes, however it did reveal a highly significant association between PLOD2 and the long non-coding RNA (lncRNA) LNCSRLR.