MIR124-3 and NKX6-1 hypermethylation profiles accurately predict metachronous gastric lesions in a Caucasian population.

On the other hand, there was a suggestive trend indicating that patients with high methylation levels of NKX6-1 might have an increased risk of developing MGL compared to those with lower methylation levels ( p = 0.062, Fig. 3 B), corresponding to a 1.7-fold increase in risk (HR = 1.73, 95% CI 0.80–3.75, p = 0.162, Table 2 ), which reached statistical significance considering the optimal cutoff value ( p = 0.021, Fig. 3 C, aHR = 2.01, 95% CI 0.93–4.33, p = 0.074, Table 2 ).

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