However, the observed difference in the number of donor samples that responded to the API and to the individual impurities was not sizable, and the difference in the intensity of response (SFCs) did not reach statistical significance (Mann–Whitney and Wilcoxon matched-paired rank tests).
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Assessing the immunogenicity risk of salmon calcitonin peptide impurities using <i>in silico</i> and <i>in vitro</i> methods.
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