Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy.

KI mice also have a lower mean and median relative brain sizes, but like the human cohort in which occipitofrontal circumference percentiles varied considerably, a high degree of variability was observed in the mice and the difference did not reach statistical significance ( M WT = 1.03, Mdn WT = 1.04, M KI = 0.97, Mdn KI = 0.94, SD WT = 0.08, SD KI = 0.10, two-tailed Mann-Whitney U , Z = −1.361, p = 0.174; Fig. 3e ).

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