One of 8 valves tested 6–7 weeks after induction was leaky, compared with 2 of 6 valves tested 18 weeks after induction, suggesting a possible trend for these valves to become leakier with time.
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Connexin-45 is expressed in mouse lymphatic endothelium and required for lymphatic valve function.
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The sentences
Despite the incompetent Lyve1-Cre Cx45 Δ/fl valves noted above, the differences between the genotypes did not reach statistical significance.