NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia.

Pathway analysis performed in Metaboanalyst using all nominally significant metabolite changes ( P ≤ 0.05, FDR < 0.2) after loss of frataxin revealed effects on arginine biosynthesis, alanine metabolism, TCA cycle, taurine metabolism, and glutathione metabolism with many of the changes common among the heart, cerebellum, and mitochondria ( Supplemental Table 2A ).

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