Histopathological growth pattern and vessel co-option in intrahepatic cholangiocarcinoma.

All statistical tests were two-sided, and p < 0.05 was deemed statistically significant, while p < 0.01 was considered highly significant.

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The density of CD8 + cells at the invasive margin tended to be higher in iCCA with prominent replacing HGPs than those with pushing or desmoplastic HGPs, but the trend did not reach statistical significance (Fig. 4 d and f and Supplemental Table 2).

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