Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted/founder sensitivity to broadly neutralizing antibodies.

T/F viruses with incompletely closed Envs were also more sensitive to sCD4, although this difference did not reach statistical significance ( P = 0.05; Supplementary Fig. 3d ); and we observed a significant correlation between cold and sCD4 sensitivity ( P = 0.0005; Fig. 1f ).

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