Fatty acid desaturase insertion-deletion polymorphism rs66698963 predicts colorectal polyp prevention by the n-3 fatty acid eicosapentaenoic acid: a secondary analysis of the seAFOod polyp prevention trial.

However, the efficacy of the same dose and formulation of EPA was modest and did not reach statistical significance (incidence rate ratio [IRR]: 0.91; 95% confidence interval [CI]: 0.79, 1.05) for the reduction in colorectal polyp number in the seAFOod 2 × 2 factorial polyp prevention trial of EPA and aspirin 300 mg daily in patients undergoing colonoscopy surveillance after removal of multiple sporadic colorectal polyps [ 6 ].

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