The management of osteosarcoma in children and adolescents in a resource-limited setting: quality improvement considerations to improve treatment outcomes.

Likewise, patients who received prior manipulative therapy ( p = 0.961) and up-front surgery ( p = 0.273) had lower median survivals compared to those who did not receive manipulative therapy and those who received pre-surgical chemotherapy, respectively, although these differences did not reach statistical significance (Table 3 ).

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