Bacterial amyloid curli activates the host unfolded protein response via IRE1α in the presence of HLA-B27.

Quantification of Il1b and Il23 mRNA expression, both cytokines associated with Th17 activation, in the cecum homogenates of wild-type STm-infected HLA-B27tg mice revealed quite high Il23 and Il1b expression in a subset of mice, but these changes did not reach statistical significance, compared to C57BL/6 mice infected with wild-type STm (Supplementary Figure S3(b,c)).

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