Extracellular Vesicles of the Probiotic <i>Escherichia coli</i> Nissle 1917 Reduce PepT1 Levels in IL-1β-Treated Caco-2 Cells via Upregulation of miR-193a-3p.

In the inflammation model, treatment of Caco-2 cells with IL-1β resulted in the downregulation of miR-193a-3p (near significance, p = 0.056) and miR-92b ( p ≤ 0.05) ( Figure 2 A).

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EVs from the commensal EcoR12 exhibited a minor protective effect, with differences that did not reach statistical significance ( Figure 4 A, Tri-DAP treatment).

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