Although a trend of improvement was evident in all cell recipients, this difference approached but did not reach statistical significance (change in right ventricular ejection fraction (RVEF): vehicle, −2% ± 4%; vehicle + AA, 2% ± 5%; PSC-CM, 8% ± 3%; PSC-CM ± AA, 5% ± 2%; P = 0.15, NS).
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Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias.
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