The role of clonal progression leading to the development of therapy-related myeloid neoplasms.

Of note, in patients with TP53 mutations at t0, both the INDEL mutations (n = 2) showed a VAF increasing over time, whereas missense mutations expanded in half of the cases (6 out of 12), but the difference did not reach statistical significance, probably due to the limited number of patients with INDEL mutations.

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