The Approved Live-Attenuated Chikungunya Virus Vaccine (IXCHIQ<sup>®</sup>) Elicits Cross-Neutralizing Antibody Breadth Extending to Multiple Arthritogenic Alphaviruses Similar to the Antibody Breadth Following Natural Infection.

Finally, for RRV T-48 , which is the most distantly related Semliki Forest antigenic complex member included in our investigation, the GMT was 32 at day 29, 33 at day 180, and 39 at day 365 post-vaccination; there was consistency of these low-level responses over time and these changes did not reach statistical significance ( Figure 1 F and Table 2 ).

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