Smoldering oncolysis by foamy virus carrying CD19 as a CAR target escapes CAR T detection by genomic modification.

In contrast, treatment of oFV-hCD19t injected tumors with anti-CD19 CAR T cells induced highly significant loss of virus in the tumors at all viral treatment doses ( Figures 5 A and 5B) (days 7–29).

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Nonetheless, there was a clear trend toward a higher frequency of deletions in the viruses recovered from mice with tumors treated with oFV-hCD19t and CAR T cells ( Figures 6 C–6E).

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