PIK3CA Mutated Colorectal Cancers Without KRAS, NRAS and BRAF Mutations Possess Common and Potentially Targetable Mutations in Epigenetic Modifiers and DNA Damage Response Genes.

Quadruple wild type cancers were also more often of the CIN phenotype (χ 2 test p=0.005) and had higher AS and FGA scores (although the latter did not reach statistical significance) as well as lower rates of elevated TMB (higher than 10 mutations/Mb, Fisher’s exact test p=0.01) (Table I).

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