Metabolic Disturbances in a Mouse Model of MPTP/Probenecid-Induced Parkinson's Disease: Evaluation Using Liquid Chromatography-Mass Spectrometry.

As seen in the OPLS-DA model of this study, the distinction between the NC group and the PD model groups was clearly evident, and there was a definite trend in the horizontal coordinate from W1 to W5 ( Figure 2A ).

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32 Our results revealed that DHEAS showed a trend of increasing and then decreasing during PD progression, suggesting that DHEAS exhibited compensatory dysregulation during early-stage PD.

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