The T2-FLAIR mismatch sign in oncologic neuroradiology: History, current use, emerging data, and future directions.

3 , 25 , 29 , 37 – 39 Similarly, the “partial” T2FMM sign did not confer a statistically significant survival advantage in high-grade gliomas of the ReSPOND cohort, although a nonsignificant trend towards slightly longer survival was observed. 23 Patel and colleagues performed a histopathologic review of 30 IDHm non-codeleted LGGs from the TCGA/TCIA cohort, 15 of which displayed T2FMM on MRI, and found a trend for the presence of microcysts in T2FMM-positive cases.

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The trend did not reach statistical significance, possibly due to the small sample size and heterogeneous quality and consistency of the tissue samples, as discussed by the authors. 3 Later, in a retrospective cohort of 64 LGGs, Deguchi and colleagues found a statistically significant association between microcysts on histopathology and the T2FMM sign.

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