IL-6 and TIMP-1 Correlated to Airway Pathogen Colonization and Predict Disease Severity in Patients with Non-Cystic Fibrosis Bronchiectasis.

Furthermore, serum levels of TIMP-1 were significantly positively correlated with the FACED score, significantly negatively correlated with DSP, and showed a trend of a positive correlation with BSI, all of which represent clinical severity and are predictors of mortality. 12 These findings suggest that serum levels of IL-6 and TIMP-1 may be primarily triggered by airway pathogens, and that they are closely associated with clinical severity.

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