Identification of Therapy-Induced Clonal Evolution and Resistance Pathways in Minimal Residual Clones in Multiple Myeloma through Single-Cell Sequencing.

In this study, we focused on the enriched cytokine/receptor interactions in selective PCs or resistant PCs and selected the cytokine/receptor interactions associated with highly significant ( P value < 0.05) and highly expressed (exp_value > 0.1) cell–cell interaction pairs in selective PCs compared with sensitive PCs or resistant PCs compared with sensitive PCs.

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Moreover, our results indicated a slightly longer OS for patients with a high selective score compared with those without a high selective score, although the difference did not reach statistical significance in the log-rank analysis ( Fig. 4D ).

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