The behavioral test results showed that the OGD-N-EVs treated mice showed a trend of worsening behavior compared to Nor-N-EVs treated mice in response to ischemic insult, including the mNSS, negative geotaxis test, Kondziella’s inverted screen test (Figure S29C-E).
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MiR-100-5p-rich small extracellular vesicles from activated neuron to aggravate microglial activation and neuronal activity after stroke.
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