Glioma oncogenesis in the Constitutional mismatch repair deficiency (CMMRD) syndrome.

The number of mutations was higher in the tumors of patients with MSH6 biallelic mutations compared to those with PMS2 biallelic mutation as the 3 patients with the highest TMB had MSH6 biallelic mutations but this difference did not reach statistical significance (median of 279 vs 170 coding SNV/Mb, respectively, P = NS, Mann Whitney Wilcoxon test).

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