The level of NeuN in AD-Nup organoids showed a trend although not statistically significant (NeuN: C-GFP 1 ± 0.02, AD-GFP 0.31 ± 0.02, AD-Nup153-GFP 0.42 ± 0.04, P < 0.05 ANOVA followed by Bonferroni test, n = 3).
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Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD.
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